Thymol Trimethoxycinnamate

THY

6/10

Concern level

Moderate concern

Synthetic aromatic ester also known as Melasolv; a thymol-derived trimethoxycinnamate used in cosmetics as a skin-protecting/antioxidant active and in research as a depigmenting candidate. PubChem lists the formula as C22H26O5 and MW 370.4 g/mol; FDA GSRS records the UNII D8643OL0EL. ([pubchem.ncbi.nlm.nih.gov](https://pubchem.ncbi.nlm.nih.gov/compound/2404683?utm_source=openai))

Pore-clogging

Low

Regulatory

No data

Benefits

Healing

Chemical Properties

Molecular Weight

370.4 g/mol

Typical Concentration

0.10% - 5.00%

CAS Number: 504394-57-4

Skin Type Compatibility

dry skin5/10

oily skin6/10

sensitive skin4/10

acne prone5/10

mature skin6/10

normal skin6/10

Interactions

incompatible with: No well-established ingredient incompatibilities were found in public authoritative sources., As a lipophilic ester, compatibility should be verified in high-water or low-solubilizer systems.

Risks & Warnings

Likely low to moderate irritation potential, but human cosmetic safety data are limited. The ingredient is an aromatic ester with some lipophilicity, so sensitization/irritation is possible in very reactive users. Evidence is stronger for experimental depigmenting activity than for broad clinical safety data. ([jstage.jst.go.jp](https://www.jstage.jst.go.jp/article/cpb/51/9/51_9_1085/_pdf))

Vegan Cruelty-Free

Found In Products

Sulwhasoo

Concentrated Ginseng Rejuvenating Eye Cream for Anti-Aging

AESTURA

ATOBARRIER365 Moisturizing Body Lotion with Ceramides for Dry & Sensitive Skin

Hanyul

Mini Yuja Brightening Sleeping Mask with Vitamin C and Niacinamide