sh-Polypeptide-3

SH-

8/10

Concern level

High concern

Peptide Compound

Synthetic recombinant peptide (former rh-Oligopeptide-5), identified as an analog of human keratinocyte growth factor/FGF-7. In cosmetics it is used primarily as a skin-conditioning, anti-aging, and regeneration-support ingredient. Public ingredient databases describe it as synthetic and commonly used in anti-aging products; the peptide is also associated with epithelial repair and keratinocyte proliferation. ([cosmileeurope.eu](https://cosmileeurope.eu/inci/detail/18687/sh-polypeptide-3))

Pore-clogging

Non-comedogenic

Regulatory

No data

Benefits

Anti-agingHealingSoothingSupports Barrier Function

Chemical Properties

Molecular Weight

18995 g/mol

pH Range

4.00 - 7.00

Typical Concentration

0.00% - 0.05%

CAS Number: 148348-15-6

Skin Type Compatibility

dry skin8/10

oily skin7/10

sensitive skin7/10

acne prone7/10

mature skin9/10

normal skin8/10

Interactions

incompatible with: Avoid prolonged exposure to very low-pH formulas if stability data are not supplied by the manufacturer., Avoid harsh oxidative systems or high-heat processing that can degrade peptides., No well-documented direct cosmetic ingredient conflicts are publicly established; compatibility should be confirmed by formulation testing.

Risks & Warnings

Overall low irritation potential, but human cosmetic safety data are limited in public sources. As a growth-factor-like peptide, the main concerns are formulation stability, contamination/quality control, and the fact that long-term pregnancy/lactation safety data are insufficient. In highly sensitive users, any peptide-containing serum can still cause mild stinging from the full formula rather than the peptide itself. ([cosmileeurope.eu](https://cosmileeurope.eu/inci/detail/18687/sh-polypeptide-3))

Vegan Cruelty-Free

Found In Products

Biodance

Collagen Gel Toner Pads for Pore Minimizing & Firming Care