Sh-Polypeptide-121

SH-

8/10

Concern level

High concern

Peptide Compound

Sh-Polypeptide-121 is a bioengineered human-identical peptide used in skincare for skin conditioning and film formation. It is generally positioned as an anti-aging support ingredient, with marketing and formulation use focused on helping improve the appearance of firmness, elasticity, and overall skin smoothness. As a large recombinant peptide/protein ingredient, it is typically used at very low levels in finished cosmetics.

Pore-clogging

Non-comedogenic

Pregnancy

Safe

Regulatory

No data

Benefits

Anti-agingFirming EffectSupports Barrier Function

Chemical Properties

pH Range

4.00 - 7.00

Typical Concentration

0.00% - 0.10%

Skin Type Compatibility

dry skin8/10

oily skin7/10

sensitive skin7/10

acne prone7/10

mature skin9/10

normal skin8/10

Interactions

incompatible with: strong oxidizers, very low pH exfoliating acids, high-heat processing, formulations with poor peptide stability

Risks & Warnings

Low overall risk profile, but any peptide-containing formula may still irritate very reactive skin depending on the full product system. Data on sensitization, pregnancy-specific concerns, and long-term clinical outcomes are limited. Because this is a high-molecular-weight bioengineered ingredient, performance depends heavily on formulation stability.

Vegan Cruelty-Free