sh-Pentapeptide-5

SH-

8/10

Concern level

High concern

Peptide Compound

sh-Pentapeptide-5 is a synthetic human-identical pentapeptide corresponding to the Leu-enkephalin sequence (Tyr-Gly-Gly-Phe-Leu). In cosmetics it is used as a skin-conditioning peptide, mainly in anti-aging and smoothing products. It is marketed for helping improve the appearance of expression lines, skin texture, and firmness, with a proposed biomimetic endorphin/neuromodulatory mechanism rather than exfoliation or barrier lipid replacement.

Pore-clogging

Non-comedogenic

Pregnancy

Safe

Regulatory

No data

Benefits

Anti-agingFirming EffectSupports Barrier Function

Chemical Properties

Molecular Weight

555.63 g/mol

pH Range

4.00 - 7.00

Typical Concentration

0.00% - 0.01%

CAS Number: 58822-25-6

Skin Type Compatibility

dry skin7/10

oily skin7/10

sensitive skin8/10

acne prone7/10

mature skin9/10

normal skin8/10

Interactions

incompatible with: No well-established direct topical ingredient conflicts are documented., If used in formulas with low pH acids or strong oxidizing systems, verify peptide stability in the finished product., As with most peptides, performance may be reduced in very harsh or highly acidic formulas.

Risks & Warnings

Overall low-risk topical ingredient, but peptide products can still cause individual irritation or sensitization from the finished formula, preservatives, solvents, or delivery system. Safety data specific to pregnancy, lactation, and long-term high-dose exposure are limited. Avoid use on compromised or very irritated skin if the formula stings or causes redness.

Vegan Cruelty-Free

Found In Products

Peter Thomas Roth