R-Bacillus Licheniformis Keratinase

R-B

5/10

Concern level

Moderate concern

Peptide Compound

A recombinant Bacillus licheniformis-derived keratinase enzyme used in cosmetics as a skin-conditioning and nail-conditioning ingredient. It is a proteolytic enzyme that breaks down keratin proteins, which is why it may be used in exfoliating or smoothing formulations and in nail-care products. COSMILE lists it as a skin-conditioning and nail-conditioning ingredient; a published biochemical study of a recombinant Bacillus licheniformis keratinase reported an approximate molecular mass of 38 kDa and optimum activity around pH 6. ([cosmileeurope.eu](https://cosmileeurope.eu/inci/detail/20221/r-bacillus-licheniformis-keratinase/))

Pore-clogging

Non-comedogenic

Pregnancy

Safe

Regulatory

No data

Benefits

SoothingImproves Texture

Chemical Properties

Molecular Weight

38000 g/mol

pH Range

5.50 - 8.00

Typical Concentration

0.05% - 1.00%

Skin Type Compatibility

dry skin4/10

oily skin6/10

sensitive skin3/10

acne prone5/10

mature skin5/10

normal skin6/10

Interactions

incompatible with: strong acids or very low pH formulas can reduce enzyme activity, strong alkalis can destabilize enzymes, oxidizing systems such as high-peroxide formulas may inactivate proteins, protease inhibitors can reduce efficacy

Risks & Warnings

Main concerns are enzyme/protein-related irritation or sensitization, especially on compromised, inflamed, or very sensitive skin. As with other proteolytic cosmetic enzymes, overuse may increase dryness or irritation if the formulation is too active. Specific human cosmetic safety data for this exact ingredient appears limited. ([skinwis.com](https://www.skinwis.com/ingredient/r-bacillus-licheniformis-keratinase?utm_source=openai))

Vegan Cruelty-Free

Found In Products

Peter Thomas Roth