Pentyelene Glycol

PEN

8/10

Concern level

High concern

A small-molecule aliphatic diol used in cosmetics primarily as a humectant, solvent, and booster for preservation. FDA GSRS lists Pentylene Glycol (UNII 50C1307PZG) as 1,2-pentanediol / 1,2-pentanediol with molecular weight 104.15 g/mol. Supplier technical sheets also describe it as a multifunctional moisturizer/solvent and preservative-support ingredient. ([precision.fda.gov](https://precision.fda.gov/ginas/app/ui/substances/9a6daa31-0bf2-4134-a179-9185554f7440?utm_source=openai))

Pore-clogging

Non-comedogenic

Pregnancy

Safe

Regulatory

No data

Benefits

MoisturizingSoothing

Chemical Properties

Molecular Weight

104.15 g/mol

pH Range

4.00 - 8.00

Typical Concentration

1.00% - 5.00%

CAS Number: 5343-92-0

Skin Type Compatibility

dry skin9/10

oily skin8/10

sensitive skin7/10

acne prone9/10

mature skin8/10

normal skin9/10

Interactions

incompatible with: No major ingredient conflicts are established; it is commonly compatible with acids, niacinamide, retinoids, and preservatives, though highly reactive/sensitized skin may still sting with strong actives.

Risks & Warnings

Generally low risk, but it can sting or cause mild irritation on compromised skin, especially in leave-on products at higher percentages. As with most glycols, sensitivity is possible in very reactive users. No strong evidence suggests it is comedogenic. ([makingcosmetics.com](https://www.makingcosmetics.com/on/demandware.static/-/Sites-makingcosmetics-master/default/dwc401bf84/fact-sheets/fact-sheet-pentylene-glycol-bio.pdf?utm_source=openai))

Vegan Cruelty-Free

Found In Products

Dr. Jart+

Cicapair™ Soothing Color Correcting Treatment SPF 30 with Centella Asiatica Extracts