Pentapeptide-48
Pentapeptide-48
PEN
9/10
Concern level
High concern
Peptide Compound
Synthetic pentapeptide (Thr-Arg-Ser-Glu-Leu) used as a skin-conditioning and anti-aging active; it is described in cosmetic databases as a peptide intended to support firmness, smoothing, and overall rejuvenation. ([inci.guide](https://inci.guide/peptides/pentapeptide-48?utm_source=openai))
Pore-clogging
Non-comedogenic
Pregnancy
Safe
Regulatory
No data
Benefits
Anti-agingFirming EffectImproves TextureSupports Barrier Function
Chemical Properties
Molecular Weight
586.7 g/mol pH Range
5.00 - 7.50Typical Concentration
0.00% - 0.10%Skin Type Compatibility
dry skin7/10
oily skin7/10
sensitive skin8/10
acne prone7/10
mature skin9/10
normal skin8/10
Interactions
incompatible with:
Risks & Warnings
Low-risk ingredient overall, but human topical safety data are limited compared with older cosmetic actives. Potential issues are mainly rare sensitivity or formulation-related instability rather than intrinsic irritation; no specific pregnancy concerns are established in the sources reviewed. ([incidecoder.com](https://incidecoder.com/ingredients/pentapeptide-48?utm_source=openai))
Vegan Cruelty-Free
