Healthy Skinfluence

Pentapeptide-4(0.1ppb)

Pentapeptide-4(0.1ppb)

PEN
8/10
Concern level
High concern
Peptide Compound

Synthetic signal peptide with the sequence Lys-Thr-Thr-Lys-Ser (KTTKS). In cosmetics it is used as an anti-aging peptide intended to support a more youthful appearance by signaling skin to support matrix/collagen-related pathways. PubChem lists the INCI as Pentapeptide-4, molecular formula C23H45N7O9, and molecular weight 563.6 g/mol; CIR reviewed Pentapeptide-4 with related pentapeptides for cosmetic use. ([pubchem.ncbi.nlm.nih.gov](https://pubchem.ncbi.nlm.nih.gov/compound/9959565?utm_source=openai))

Pore-clogging
Non-comedogenic
Pregnancy
Safe
Regulatory
No data

Benefits

Boosts Collagen ProductionAnti-agingSupports Barrier Function

Chemical Properties

Molecular Weight
563.6 g/mol
pH Range
4.00 - 7.00
Typical Concentration
0.00% - 0.01%
CAS Number: 149128-48-3

Skin Type Compatibility

dry skin8/10
oily skin8/10
sensitive skin8/10
acne prone7/10
mature skin9/10
normal skin9/10

Interactions

incompatible with: avoid prolonged exposure to very low pH formulas, avoid high-heat processing after addition, use caution combining with strongly oxidizing or highly alkaline systems

Risks & Warnings

Generally low-risk in topical cosmetic use. Main concerns are uncommon irritation, sensitivity to the full formulation, or reduced stability if the peptide is exposed to extreme pH, heat, or prolonged storage. No inherent comedogenicity is expected for the peptide itself. ([cir-safety.org](https://cir-safety.org/supplementaldoc/safety-assessment-myristoyl-pentapeptide-4-palmitoyl-pentapeptide-4-and-pentapeptide?utm_source=openai))

Vegan Cruelty-Free

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