palmitoyl heptapeptide-27

PAL

8/10

Concern level

High concern

Peptide Compound

A synthetic palmitoylated peptide used as a skin-conditioning active. CosIng/COSMILE describe it as a peptide-based cosmetic ingredient; INCI Dictionary wording identifies it as the reaction product of palmitic acid chloride and heptapeptide-27. It is used mainly in barrier-support, smoothing, and anti-aging formulations. ([cosmileeurope.eu](https://cosmileeurope.eu/inci/detail/22441/palmitoyl-heptapeptide-27/?utm_source=openai))

Pore-clogging

Non-comedogenic

Pregnancy

Safe

Regulatory

No data

Benefits

Anti-agingFirming EffectImproves TextureSupports Barrier Function

Chemical Properties

pH Range

4.50 - 7.50

Typical Concentration

0.00% - 0.01%

Skin Type Compatibility

dry skin8/10

oily skin6/10

sensitive skin7/10

acne prone6/10

mature skin9/10

normal skin8/10

Interactions

incompatible with: No specific ingredient conflicts are established., As a peptide, it is best paired with gentle, non-extreme-pH formulations; avoid very low-pH acid systems if the finished product is intended to keep peptide integrity high.

Risks & Warnings

Low inherent hazard is expected, but data are limited compared with older cosmetic actives. Possible concerns are rare sensitivity, formulation instability if poorly preserved, and theoretical comedogenic contribution from the palmitoyl moiety only in very rich formulas, not from the peptide itself. ([cosmileeurope.eu](https://cosmileeurope.eu/inci/detail/22441/palmitoyl-heptapeptide-27/?utm_source=openai))

Vegan Cruelty-Free

Found In Products

rhode

Barrier Restore Cream Comforting Daily Moisturizer