Oxidized Glutathione

OXI

8/10

Concern level

High concern

Peptide Compound

Oxidized glutathione (glutathione disulfide, GSSG) is the disulfide form of glutathione, a naturally occurring tripeptide antioxidant. In cosmetics it is used mainly as an antioxidant/conditioning active and sometimes in brightening-oriented formulas. Compared with many acids or retinoids, it is typically considered low-irritation, but performance in topical skincare depends strongly on formula stability and delivery system. ([pubchem.ncbi.nlm.nih.gov](https://pubchem.ncbi.nlm.nih.gov/compound/Oxiglutatione?utm_source=openai))

Pore-clogging

Non-comedogenic

Pregnancy

Safe

Regulatory

No data

Benefits

BrighteningSupports Barrier Function

Chemical Properties

Molecular Weight

612.63 g/mol

pH Range

4.00 - 7.00

Typical Concentration

0.10% - 2.00%

CAS Number: 27025-41-8

Skin Type Compatibility

dry skin7/10

oily skin7/10

sensitive skin8/10

acne prone7/10

mature skin8/10

normal skin8/10

Interactions

incompatible with: Strong oxidizing systems, Strong reducing agents, Very low-pH exfoliating formulas if stability testing is not confirmed, Highly reactive metal-ion rich systems unless properly chelated

Risks & Warnings

Topical safety concerns are generally low, but data specific to oxidized glutathione in cosmetics are limited. Potential issues include mild irritation in very sensitive skin, and reduced efficacy if the formula is poorly stabilized or exposed to incompatible oxidation/reduction conditions. Because cosmetic products in the EU still require a product-level safety assessment, use should be based on finished-product testing rather than ingredient identity alone. ([skinwis.com](https://www.skinwis.com/ingredient/oxidized-glutathione?utm_source=openai))

Vegan Cruelty-Free