Healthy Skinfluence

Hexapeptide-12(0.1ppb)

Hexapeptide-12(0.1ppb)

HEX
9/10
Concern level
High concern
Peptide Compound

Hexapeptide-12 is a synthetic six-amino-acid peptide (Val-Gly-Val-Ala-Pro-Gly) used in skincare as a skin-conditioning, anti-aging peptide. It is a small, water-soluble peptide that is generally used at very low concentrations and is intended to support the appearance of smoother, firmer skin rather than exfoliate or cleanse. CIR reviewed hexapeptide-12 and related peptides and concluded they are safe in present cosmetic practices and concentrations.

Pore-clogging
Non-comedogenic
Pregnancy
Safe
Regulatory
No data

Benefits

Anti-agingSupports Barrier Function

Chemical Properties

Molecular Weight
498.57 g/mol
pH Range
4.00 - 7.00
Typical Concentration
0.00%
CAS Number: 70592-18-6

Skin Type Compatibility

dry skin8/10
oily skin7/10
sensitive skin8/10
acne prone7/10
mature skin9/10
normal skin9/10

Interactions

incompatible with: No well-established incompatibilities in typical cosmetic use, Potential irritation may increase when combined in the same routine with strong exfoliating acids, Complex formulas with fragrance or high-preservative loads may reduce tolerability in sensitive skin

Risks & Warnings

Overall low-risk, but any peptide can rarely cause irritation or sensitization in very reactive skin. Because it is often used in complex formulas, reactions may also come from the surrounding vehicle, preservatives, fragrance, or other actives. Pregnancy-specific data are limited.

Vegan Cruelty-Free

Similar Ingredients