Edetate Disodium Anhydrous
Edetate Disodium Anhydrous
EDE
9/10
Concern level
High concern
Disodium EDTA anhydrous is a chelating agent that binds metal ions to improve product stability, reduce discoloration, and enhance preservative performance. It does not provide direct skin treatment benefits, but helps formulas remain effective over time.
Pore-clogging
Non-comedogenic
Pregnancy
Safe
Regulatory
No data
Benefits
Supports Barrier Function
Chemical Properties
Molecular Weight
336.21 g/mol pH Range
4.00 - 8.00Typical Concentration
0.01% - 0.50%CAS Number: 139-33-3
Skin Type Compatibility
dry skin9/10
oily skin9/10
sensitive skin8/10
acne prone9/10
mature skin9/10
normal skin9/10
Interactions
incompatible with: No major direct skin-interaction conflicts are established., Most useful in formulas containing water, preservatives, or oxidation-prone actives; it can improve stability rather than conflict with them.
Risks & Warnings
Generally low risk at cosmetic use levels. Possible mild eye/skin irritation in sensitive users. In higher-exposure non-cosmetic settings, EDTA salts can contribute to mineral chelation concerns; topical cosmetic use is considered safe in the CIR review data.
Vegan Cruelty-Free
Found In Products
Differin
Differin Adapalene Prescription Strength Retinoid Gel 0.1% Acne Treatment (Up to 90 Day Supply), 45 Gram
La Roche-Posay