Diosmine

DIO

8/10

Concern level

High concern

Diosmine (diosmin) is a citrus-derived flavonoid glycoside used in some cosmetic formulas for its antioxidant and soothing/conditioning properties, especially in products marketed for redness-prone or vascular-appearance concerns. It is not an exfoliating acid or vitamin; rather, it is a plant polyphenol with barrier-supportive and anti-inflammatory potential. In skin care it is typically used as a low-dose active or supportive ingredient in leave-on serums, eye products, and creams.

Pore-clogging

Non-comedogenic

Regulatory

No data

Benefits

Soothing

Chemical Properties

Molecular Weight

608.5 g/mol

pH Range

4.00 - 7.50

Typical Concentration

0.10% - 2.00%

CAS Number: 520-27-4

Skin Type Compatibility

dry skin6/10

oily skin5/10

sensitive skin7/10

acne prone5/10

mature skin7/10

normal skin7/10

Interactions

incompatible with: No well-established ingredient incompatibilities are documented for topical cosmetic use., In very sensitive formulas, combining with high levels of exfoliating acids or retinoids may increase perceived irritation (formulation-dependent)., If used in a product with fragrance/essential oils, irritation risk may be higher due to the overall formula rather than diosmine itself.

Risks & Warnings

Generally low hazard in topical cosmetic use, but data for long-term dermal exposure are limited. Potential concerns include mild irritation or sensitization in very reactive skin, especially in complex formulas with fragrances, acids, or other actives. Avoid use on broken skin if the finished product stings or causes redness. Oral supplement safety data do not automatically translate to topical cosmetic safety.

Vegan Cruelty-Free

Found In Products

Dermalogica

Awaken Peptide Depuffing Eye Gel

Paula's Choice