Dimethyl Isosorbide (and) Hydroxypinacolone Retinoate

DIM

5/10

Concern level

Moderate concern

Retinoid Compound

A retinoid active blend in which hydroxypinacolone retinoate (HPR) is dissolved in dimethyl isosorbide, a solvent/penetration enhancer. HPR is a retinoic-acid-ester type ingredient used for anti-aging, texture refinement, and acne-prone skin formulations, generally positioned as a retinoid with a milder irritation profile than tretinoin but still requiring caution. PubChem/FDA substance records list HPR with molecular formula C26H38O3 and molecular weight 398.58. ([precision.fda.gov](https://precision.fda.gov/ginas/app/ui/substances/NJ3V2F02E1?utm_source=openai))

Pore-clogging

Non-comedogenic

Pregnancy

Caution

Regulatory

No data

Benefits

Boosts Collagen ProductionAnti-agingImproves Texture

Chemical Properties

Molecular Weight

398.58 g/mol

Typical Concentration

0.10% - 2.00%

Skin Type Compatibility

dry skin5/10

oily skin6/10

sensitive skin2/10

acne prone6/10

mature skin8/10

normal skin5/10

Interactions

incompatible with: Avoid combining at the same time with other retinoids., Avoid or separate from high-strength AHAs/BHAs and other exfoliating acids if irritation occurs., Use caution with benzoyl peroxide, which may increase dryness and irritation when layered with retinoids., Do not use on the same routine step with products that already cause significant stinging or barrier disruption. ([incidecoder.com](https://incidecoder.com/ingredients/granactive-retinoid?utm_source=openai))

Risks & Warnings

Can cause dryness, peeling, redness, and irritation, especially when first introduced or when combined with other strong actives. Like other retinoids, it is generally avoided during pregnancy as a conservative safety practice. Sun sensitivity is a practical concern, so daily sunscreen is recommended. ([accessdata.fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/020380Orig1s010MedR.pdf?utm_source=openai))

Vegan Cruelty-Free

Found In Products

Sunday Riley