Decapeptide-4

DEC

8/10

Concern level

High concern

Peptide Compound

Synthetic cosmetic peptide used as a skin-conditioning and anti-aging active. It is described as a ten-amino-acid peptide that mimics Somatomedin C/IGF-1 signaling and is marketed for skin renewal, firmness, and smoothing. Evidence available in public sources is largely supplier- and database-based rather than robust independent clinical data. ([incidecoder.com](https://incidecoder.com/ingredients/decapeptide-4))

Pore-clogging

Non-comedogenic

Pregnancy

Safe

Regulatory

No data

Benefits

Anti-agingFirming EffectHealingImproves TextureSupports Barrier Function

Chemical Properties

Molecular Weight

1301.6 g/mol

pH Range

4.50 - 7.00

Typical Concentration

0.00% - 0.01%

CAS Number: 2227218-71-3

Skin Type Compatibility

dry skin7/10

oily skin6/10

sensitive skin8/10

acne prone7/10

mature skin9/10

normal skin8/10

Interactions

incompatible with: No well-established ingredient incompatibilities are publicly documented for Decapeptide-4., Formulation compatibility should be verified with strong acids, extreme pH systems, and high-oxidation environments because peptide stability can be formulation-sensitive.

Risks & Warnings

Low documented irritation potential overall, but topical peptides can still cause rare sensitivity or formulation-related irritation. Because Decapeptide-4 is a growth-factor-mimetic peptide, conservative formulators should avoid overstating medicinal or wound-healing claims. Robust independent safety and pregnancy-specific data are limited in public sources. ([incidecoder.com](https://incidecoder.com/ingredients/decapeptide-4))

Vegan Cruelty-Free

Found In Products

IOPE